In theory, Motif Neurotech's berry-sized device would work like a continuous glucose monitor. More information Adding us as a Preferred Source in Google by using this link indicates that you would like to see more of our content in Google News results. Patients receiving the experimental new implant would not need to undergo a complicated surgery. Breakthroughs, discoveries, and DIY tips sent six days a week. Earlier this week, the United States Food and Drug Administration (FDA) approved a human trial for a blueberry-sized brain implant intended to target treatment-resistant depression.

The LinkedIn cofounder now has an AI drug discovery startup--and thinks not asking chatbots for medical advice is "bordering on committing malpractice." Following a three-decade career at the helm of some of Silicon Valley's most powerful companies--cofounding LinkedIn and sitting on the boards of PayPal and OpenAI-- Reid Hoffman recently turned his attention to health care. Hoffman's startup, Manas AI, is building an AI engine that aims to fast-track the traditionally slow process of drug discovery for various cancers. Inspired by a dinner with renowned cancer physician Siddhartha Mukherjee, the company's cofounder and CEO, its mission statement is to "shift drug discovery from a decade-long process to one that takes a few years." But Hoffman's enthusiasm for generative AI, in particular, stretches far beyond novel drug targets and small molecules.

Aleksandra Mendoza, aka Alorah Ziva, alleges that the 20-year-old influencer injected her with drugs on a livestream and had nonconsensual sex with her while she was underage. An 18-year-old woman who promotes herself as the "#1 female looksmaxxer" is suing the highly controversial streamer Braden Eric Peters, aka Clavicular, for fraud, battery, and alleged sexual assault. In the suit, which was filed in Miami-Dade County court and obtained by WIRED, Aleksandra Mendoza, who goes by the name @zahloria, or Alorah Ziva, on Instagram, alleges that she first encountered Peters in May 2025, when she was just 16 years old. According to the complaint, Peters promised Mendoza he could make her "the female face of looksmaxxing," the online trend of using surgery or drugs to enhance one's facial features. Eager to grow her social media following, Mendoza agreed to make four looksmaxxing videos for Peters in exchange for a $1,000 payment, court documents say.

China races to build record biobank to rival U.S. drugs research Biobanks store masses of biomedical data such as clinical records, genome sequences and other long-term health metrics that research and drug development depend on. As a fledgling researcher in U.S., Zhang Li was struck by the efficiency of extracting human tissue in the morning and mining it for data the same afternoon. Such a streamlined process had been missing from his years of training as a bio data scientist in China. Inspired, he returned home to Beijing to join the Chinese Institute for Brain Research and launch a national database that will collect blood and DNA samples from 33,000 children to help identify patterns of brain disease and their risk factors. "Biomedical data is extremely valuable and is fundamental for us to find solutions to diseases and to delay aging," said Zhang, surrounded by robotic arms carefully organizing blood samples.

Nicotine pouches are revered among tech workers, who tout them as the perfect brain-boosting, productivity-jacking stimulants. Entrepreneur Garrett Campbell has a 6-mg "cool mint" Zyn tucked under his lip at all times during his mammoth 15-hour workdays, aside from when he is eating. "I was always very against nicotine," says the software company founder. The 26-year-old saw his peers using nicotine pouches at college, when they first emerged as a potential productivity-boosting hack, and considered it a "degenerate thing to do." But then all of his fellow founders started fueling themselves with nicotine pouches, of which the Philip Morris International-owned Zyn is the market leader.

Isomorphic Labs president Max Jaderberg said at WIRED Health in London that the startup has built a "broad and exciting pipeline of new medicines." Google DeepMind's AlphaFold has already revolutionized scientists' understanding of proteins . Now, the ability of the platform to design safe and effective drugs is about to be put to the test. Isomorphic Labs, the UK-based biotech spinoff of Google DeepMind, will soon begin human trials of drugs designed by its Nobel Prize-winning AI technology. "We're gearing up to go into the clinic," Isomorphic Labs president Max Jaderberg said on April 16 at WIRED Health in London.

Bootstrap Bio and Manhattan Genomics, which were pursuing gene editing in human embryos to prevent serious disease, have shut down. Two companies that launched last year with plans to create gene-edited babies have already shut down, citing money issues and internal conflict. One of them, Manhattan Genomics of New York, closed abruptly shortly after announcing a team of scientific advisers in October that included a prominent fertility doctor, a data scientist who worked for de-extinction company Colossal Biosciences, and a scientist who pioneered a "three-parent" IVF technique. The other, California-based Bootstrap Bio, said it ceased operations in late 2025, as first reported by Mother Jones. Manhattan Genomics and Bootstrap Bio had ambitions to edit DNA in human embryos with the goal of preventing serious disease in babies.

In many application domains (e.g., recommender systems, intelligent tutoring systems), the rewards associated to the actions tend to decrease over time. This decay is either caused by the actions executed in the past (e.g., a user may get bored when songs of the same genre are recommended over and over) or by an external factor (e.g., content becomes outdated). These two situations can be modeled as specific instances of the rested and restless bandit settings, where arms are rotting (i.e., their value decrease over time). These problems were thought to be significantly different, since Levine et al. (2017) showed that state-of-the-art algorithms for restless bandit perform poorly in the rested rotting setting. In this paper, we introduce a novel algorithm, Rotting Adaptive Window UCB (RAW-UCB), that achieves near-optimal regret in both rotting rested and restless bandit, without any prior knowledge of the setting (rested or restless) and the type of non-stationarity (e.g., piece-wise constant, bounded variation). This is in striking contrast with previous negative results showing that no algorithm can achieve similar results as soon as rewards are allowed to increase. We confirm our theoretical findings on a number of synthetic and dataset-based experiments.

We study semisupervised mean estimation with a small labeled sample, a large unlabeled sample, and a black-box prediction model whose output may be miscalibrated. A standard approach in this setting is augmented inverse-probability weighting (AIPW) [Robins et al., 1994], which protects against prediction-model misspecification but can be inefficient when the prediction score is poorly aligned with the outcome scale. We introduce Calibrated Prediction-Powered Inference, which post-hoc calibrates the prediction score on the labeled sample before using it for semisupervised estimation. This simple step requires no retraining and can improve the original score both as a predictor of the outcome and as a regression adjustment for semisupervised inference. We study both linear and isotonic calibration. For isotonic calibration, we establish first-order optimality guarantees: isotonic post-processing can improve predictive accuracy and estimator efficiency relative to the original score and simpler post-processing rules, while no further post-processing of the fitted isotonic score yields additional first-order gains. For linear calibration, we show first-order equivalence to PPI++. We also clarify the relationship among existing estimators, showing that the original PPI estimator is a special case of AIPW and can be inefficient when the prediction model is accurate, while PPI++ is AIPW with empirical efficiency maximization [Rubin et al., 2008]. In simulations and real-data experiments, our calibrated estimators often outperform PPI and are competitive with, or outperform, AIPW and PPI++. We provide an accompanying Python package, ppi_aipw, at https://larsvanderlaan.github.io/ppi-aipw/.

Snoretox-1 uses inactive tetanus to help keep airways open. More information Adding us as a Preferred Source in Google by using this link indicates that you would like to see more of our content in Google News results. Humans bred dogs that can't breathe. Science may finally give them some relief. Breakthroughs, discoveries, and DIY tips sent six days a week.